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Relevant literature:   Review articles & patent applications:   Duetz, W.A., Chase, M., Bills, G. (2010)  Miniaturization of Fermentations. Chapter 8, ASM Manual of Industrial Microbiology and Biotechnology, R. H. Baltz, J. E. Davies, A. L. Demain (eds) Duetz, W.A. November 2008. An apparatus and a method for investigation of microtiter plates subjected to orbital shaking. Patent 86185NL00 (note: this patent application concerns the application of flatbed scanning technology for the quantification of biomass in microtiter plate wells during a short interruption in their orbital shaking) Duetz, W.A. (2007) Microtiter plates as mini-bioreactors: miniaturization of fermentation methods, TRENDS in Microbiology 15 (10): 470-475 Duetz, W.A., Kuhner M., Lohser R. (2006) Microbial and cell growth in microtiter plates, GENETIC ENGINEERING NEWS 26 (11): 44-46 JUN 1 2006   Key research article: Duetz, W.A., Rüedi, L., Hermann, R. O'Connor, K, Büchs, J., and Witholt, B. (2000). Methods for intense aeration, growth, storage, and replication of bacterial strains in microtiter plates. Applied and Environmental Microbiology 66:2641-2646 (pdf-file, 146kb)     Other articles: Minas, W., Bailey, J.E., Duetz, W.A. (2000). Streptomycetes in microcultures: growth, production of secondary metabolites, and storage and retrieval in the 96- well format. Antonie van Leeuwenhoek, 78 (3-4): 297-305 Clerval, R., Kühner, M., Li, Z., Minas, W., Fjällman, A., Witholt, B. and Duetz, W.A. (2000). The come-back of high-throughput screening of wild-type microbial strains through the use of miniaturised growth systems and LC-MS. Bioworld 6: 24-26 Duetz, W.A. and Witholt, B. (2001). Effectiveness of orbital shaking for the aeration of suspended bacterial cultures in square deepwell microtiter plates. Biochemical Engineering Journal, 7: 113-115 Duetz, W.A., Minas, W., Kuhner, M., Clerval, R., Fjallman, A.H.M., Witholt, B. (2001). Miniaturized microbial growth systems in screening. Bioworld 2: 8-10 Duetz, WA, Witholt, B. (2004). Oxygen transfer by orbital shaking of square vessels and deepwell microtiter plates of various dimensions. Biochemical Engineering Journal 17: 181-185 Articles on the cultivation of CHO-cells, using our products: Henning Gram Hansen1 Claes Nymand Nilsson, Anne Mathilde Lund, Stefan Kol, Lise Marie Grav, Magnus Lundqvist, Johan Rockberg, Gyun Min Lee, Mikael Rørdam Andersen & Helene Faustrup Kildegaard (2015) . Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells. Scientific Reports 5, Article number: 18016  (applying our 96 square half deepwell plates CR1496c , and our sandwich covers CR1396b) Kirti Chaturvedi∗, Susan Y. Sun, Thomas O’Brien, Yan J. Liu, James W. Brooks (2014). Comparison of the behavior of CHO cells during cultivation in 24-square deep well microplates and conventional shake flask. Biotechnology Reports 1–2 (2014) 22–26 (applying our 24 square deepwell plates CR1424c, and our covers CR1224c) N. J. Silk, S. Denby, G. Lewis, M. Kuiper, D. Hatton, R. Field, F. Baganz, Gary J. Lye (2010) Fed-batch operation of an industrial cell culture process in shaken microwells. Biotechnology Letters 32:73–78 (applying Corning 24 roundwell plates, and our sandwich covers CR1524a)